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OTC Zyrtec is essentially the same medication. Very similar: Zyrtec is the brand name for the molecule cetirizine, whereas xyzal is levocetirizine, the mirror image. Many studies have found Zyrtec to be more effective than Xyzal, but some studies have favored Xyzal. The human body only uses the R-enantiomer, which is why some people feels its faster and better as your body only digest pure R-enantiomer rather digest both S/R at the same time Very similar: Zyrtec is the brand name for the molecule cetirizine, whereas xyzal is levocetirizine, the mirror image. I feel that it works better than the Zyrtec. Ze veroorzaken ook minder vaak slaperigheid in vergelijking met eerste-generatie antihistaminica zoals Benadryl (difenhydramine) Xyzal vs Zyrtec. Although the medications are sold over the counter, it is important that you speak to your doctor before taking Xyzal or Zyrtec if you have any of the following conditions: Kidney disease. Edit: Xyzal does make me sleepy but since it lasts for 24 hrs I just take it an hour before bed and have no issues. At the end of the day, the best way to decide between the two is to discuss them with your doctor Explore our chart below to compare XYZAL ® vs. So, when looking for a smaller tablet, consider Xyzal. 15 thanks Answer (1 of 6): After I finish answering this question, some will accuse me of being a supporter of Bernie Sanders, which I am not, and a fanatic consumer advocate, which I am Xyzal tablets contain 5 mg levocetirizine, which corresponds Zyrtec tablets which contain 10 mg cetirizine. Cetirizine is a second generation antihistamine made up equally of two molecules that are the mirror images of each other, one is levocetirizine the other is dextrocetirizine The main difference between the two products is in the size of pill; Xyzal pills are nearly half the size as Zyrtec pills. However, FDA approved antihistamines like Xyzal, Diphenhydramine, and Zyrtec do carry some risks of use, particularly for people with certain medical conditions. But then again I have been doing shots for a while and my allergies are better so it is hard to say. ZYRTEC ® provides powerful allergy relief on your worst allergy symptoms 3 and works fast 2 and lasts all day and all night However, FDA approved antihistamines like Xyzal, Diphenhydramine, and Zyrtec do carry some risks of use, particularly for people with certain medical conditions. ZYRTEC ® to help you decide if ZYRTEC ® or XYZAL ® is the right allergy medicine for you. Sahba Ferdowsi and 3 doctors agree. However, the results do indicate that Zyrtec is slightly more effective at treating symptoms of allergic rhinitis than Xyzal Zowel Xyzal als Zyrtec hebben een snelle verlichting van allergiesymptomen aangetoond, vaak met een merkbare verbetering na één uur na het nemen van de medicatie. Zowel Xyzal als Zyrtec hebben een snelle verlichting van allergiesymptomen aangetoond, vaak met een merkbare verbetering na één uur na het nemen van de medicatie. Xyzal is slightly less drowsy, so if drowsiness is an issue with your allergy medicine, Xyzal is better than Zyrtec. As you can see, a side-by-side comparison of Xyzal vs Zyrtec highlights primary differences as well as similarities between the two medicines On the Hives Guy website, I am seeing that people talking about Xyzal working better than Zyrtec. To me it is worth a shot to try it! On first dose, Xyzal provides the same relief as Zyrtec. † So, when looking for a smaller tablet, consider Xyzal. 3k views Reviewed >2 years ago. Although it works fast, Zyrtec (cetirizine)'s effectiveness wears off for some people over time. You can try Zyrtec to see if it works as well. Both Zyrtec and Xyzal are available over-the-counter ( OTC ) Zowel Xyzal als Zyrtec hebben een snelle verlichting van allergiesymptomen aangetoond, vaak met een merkbare verbetering na één uur na het nemen van de medicatie. 15 thanks Xyzal (Levocetirizine) is similar to Zyrtec, another allergy medication, so if you can't take Zyrtec, you won't be able to take Xyzal (Levocetirizine). They’re both marketed as providing. Xyzal came to market when zyrtec was going ge Read More. The main difference between the two products is in the size of pill, Xyzal pills are nearly half the size as Zyrtec pills. Press question mark to learn the rest of the keyboard shortcuts. Some people say that Xyzal is a more 'purified" form of the chemical. Studies have been conducted that compare the effectiveness of Xyzal and Zyrtec (even Claritin, Loratadine and Allegra), and they indicate that both medications are highly effective over a 12 week study period. 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Xyzal is usually prescribe as 5mg/tablet (pure R-enantiomer) while zyrtec is prescribe as 10mg/tablet (50% S-enantiomer and 50% R-enantiomer).